Assessment of subunit-dependent direct gating and allosteric modulatory effects of carisoprodol at GABAA receptors
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چکیده
منابع مشابه
Modulatory Effects of Eschscholzia californica Alkaloids on Recombinant GABAA Receptors
The California poppy (Eschscholzia californica Cham.) contains a variety of natural compounds including several alkaloids found exclusively in this plant. Because of the sedative, anxiolytic, and analgesic effects, this herb is currently sold in pharmacies in many countries. However, our understanding of these biological effects at the molecular level is still lacking. Alkaloids detected in E. ...
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Elucidation of the Mechanism of Action of Carisoprodol at GABAA Receptors
Carisoprodol is a frequently prescribed muscle relaxant. In recent years, this drug has been increasingly abused. The effects of carisoprodol have been attributed to its metabolite, meprobamate, a controlled substance that produces sedation via GABAA receptors (GABAARs). Given the structural similarities between carisoprodol and meprobamate, we used electrophysiological and behavioral approache...
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GABAA receptors mediate the majority of the fast inhibition in the mature brain and play an important role in the pathogenesis of many neurological and psychiatric disorders. The αβδ GABAA receptor localizes extraor perisynaptically and mediates GABAergic tonic inhibition. Compared with synaptically localized αβγ receptors, αβδ receptors are more sensitive to GABA, display relatively slower des...
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ژورنال
عنوان ژورنال: Neuropharmacology
سال: 2015
ISSN: 0028-3908
DOI: 10.1016/j.neuropharm.2015.04.007